290 Main Street in Johnson City is a rare opportunity right in the heart of the action, just a one-minute walk from UHS Wilson Medical Center. The residential units were mostly updated in 2025 and are a perfect fit for travel nurses or medical staff, with the ability to bring in $750–$850 per bed—well above what the market typically gets. The ground floor commercial space is wide open and ready for a new owner or tenant to build out however they want, whether that’s retail, office, or something medical-related. Sitting on a busy corner with a traffic light, the property gets constant visibility as drivers and pedestrians can’t help but notice it. The brick construction means less maintenance over the long run, and both the front and rear entrances make all three floors easy to access. A brand-new roof was installed in 2024, adding peace of mind and reducing capital expenses for years to come. Between the updated apartments, strong rental demand, and prime corner location, this is the kind of property that doesn’t hit the market often and won’t be available for long. Walk Score 70. Please take note that the expenses are estimated based on comp sales as the building is mostly vacant at the moment.